Here, we showed that LrB can upregulate GPR120, LKB1, and AMPK in PCOS-IR rat ovaries, downregulate NLRP3 and Caspase-1, reduce insulin resistance, alleviate chronic inflammation, and ameliorate symptoms in PCOS-IR rats, by restoring the estrous cycle, reducing the number of cystic follicles, and normalizing hormone levels. This evidence concerns the gene FFAR4 and Insulin resistance.