Genome-wide association study (GWAS) and meta-analysis of candidate gene studies have identified numerous variants in several genes that are associated with both the lipid phenotype and CAD such as SORT1, LPA, LPL, APOA5, APOB, APOC3, APOE, ANGPTL3, PCSK9, NPC1L1, and HMGCR [35]. This evidence concerns the gene PCSK9 and coronary artery disorder.