Inhibiting HIF1α with 2MeOE2 and inhibiting mitophagy with CsA further confirmed that the HIF1α/BNIP3 pathway was activated in Immp2l deficiency-induced granulosa cell senescence, and that HIF1α/BNIP3 was regulated by STAT1. Here, HIF1A is linked to hyperinsulinemic hypoglycemia, familial, 4.