The authors have found that the variations with the largest effects on all three BP traits, especially diastolic BP, and the four preeclampsia-associated variations at rs419076 of the MECOM, rs16998073 of the FGF5, rs3184504 of the SH2B3, and rs6015450 of the ZNF831, and rs6015450 of the ZNF831 are in Linkage Disequilibrium (r2  =  0.74 in European), so they all may impact on the pregestation BP and, therefore, could be a risk factor for that trait and not PE as an independent pathology [19]. This evidence concerns the gene SH2B3 and preeclampsia.