Additionally, the expressions of NOS (iNOS, eNOS, and nNOS), HIF-1α, and NRF2 were significantly suppressed in the MetS group and the MetS + OVX group in comparison with the control group, whereas the expressions of NFκB-P65, DNP, and nitrotyrosine were significant overexpressed (Figure 8). The gene discussed is NOS3; the disease is metabolic syndrome.