All protein expressions in the MetS group, the MetS + L-NAME group, the MetS + OVX group, and the MetS + OVX + L-NAME group were significantly reduced compared to the control group (E-Cadherin: F (6, 35) = 49.9328, p < 0.0001; CK-14: F (6, 35) = 13.2992, p < 0.0001; C-kit: F (6, 35) = 17.0987, p < 0.0001; PDGFR: F (6, 35) = 12.3221, p < 0.0001; Vimentin: F (6, 35) = 31.5924, p < 0.0001). The gene discussed is PDGFRB; the disease is metabolic syndrome.