It was hypothesized that NO has a therapeutic effect by increasing bladder angiogenesis and neurogenesis and decreasing oxidative stress, thereby improving detrusor overactivity via nuclear factor erythroid 2-related factor 2 (NRF2) and hypoxia-inducible factor-1α (HIF-1α) activation in a rat model with MetS with or without OHD. The gene discussed is HIF1A; the disease is metabolic syndrome.