For Western Blot analysis, the markers of neurofilament, NeuN, GFAP, P2X3, and P2X7 were significantly suppressed in the MetS group and the MetS + OVX group as compared with the control group, whereas the expressions of M2 and M3 were meaningfully increased (Neurofilament: F (6, 35) = 23.4399, p < 0.0001; NeuN: F (6, 35) = 9.4984, p < 0.0001; GFAP: F (6, 35) = 22.6599, p < 0.0001; M2: F (6, 35) =29.3770, p < 0.0001; M3: F (6, 35) = 22.3518, p < 0.0001; P2X3: F (6, 35) = 39.8812, p < 0.0001; P2X7: F (6, 35) = 81.2329, p < 0.0001). The gene discussed is P2RX7; the disease is metabolic syndrome.