The expressions of all NOS, HIF-1α, and NRF2 were significantly suppressed in the MetS group and the MetS + OVX group in comparison with the control group, whereas the expressions of NFκB-P65, DNP, and nitrotyrosine were significantly overexpressed (iNOS: F (6, 35) = 47.8491, p < 0.0001; eNOS: F (6, 35) = 43.3941, p < 0.0001; nNOS: F (6, 35) = 9.1644, p < 0.0001; HIF-1α: F (6, 35) =50.2806, p < 0.0001; NRF2: F (6, 35) = 44.9870, p < 0.0001; NFκB-p65: F (6, 35) = 27.1131, p < 0.0001; DNP: F (6, 35) =70.1759, p < 0.0001; Nitrotyrosine: F (6, 35) = 42.7615, p < 0.0001). The gene discussed is HIF1A; the disease is metabolic syndrome.