Additionally, the markers of neurofilament, NeuN, GFAP, P2X3, and P2X7 were obviously increased in the MetS + L-arginine group, the MetS + OVX + L-arginine group, the MetS + L-NAME group, and the MetS + OVX + L-NAME group as compared with the MetS group and the MetS + OVX group (Figure 7I). Here, P2RX7 is linked to metabolic syndrome.