When plotting the LFC of some typical genes involved in vascular function, as provided by Metascape, e.g., genes involved in regulation of endothelial permeability (Angpt1, Tjp3, Tek, and Ocln), platelet aggregation (Tbxa2r), transport of metabolites (Slc genes), complement activation (Crp), vascular tone (Arhgap42), antioxidant activity (Sod3 and Gpx1), and nitric oxide generation (Ddah1), a strong downregulation of the genes in murine sepsis was observed. The gene discussed is SOD3; the disease is Sepsis.