ESR1 and breast cancer: Food of aquatic origin is an important source of human exposure to methylmercury and other endocrine disruptors and even a low level of exposure can induce BC cell proliferation through the activation of ER, ERK1/2, JNK, NADPH-oxidase, and NRF2 signaling, combined with anti-apoptotic and pro-survival signaling, the accumulation of DNA modifications, and the inhibition of DNA repair machinery.