INS and breast carcinoma: The intake of milk and dairy products has been related to a higher risk of breast and prostate cancers, due to the positive association with systemic levels of insulin-like growth factor 1 (IGF-1), insulin and estrogen signaling [305,306], and the IGF signaling pathway, implicated in the regulation of breast cancer stem cells (BCSCs), EMT, local migration and invasion, angiogenesis, and chemotherapy resistance [307].