MFGE8 and breast cancer: Thus, lactadherin/milk fat globule-EGR factor 8 (MFG-E8) is a glycoprotein associated with the milk fat globule membrane that plays crucial roles in cell adhesion and the promotion of angiogenesis, thus overexpressed lactadherin has been associated with poor prognosis and low survival in BC and other types of malignancies [314].