These nutritional patterns combined with specific therapeutic drugs reduce circulating insulin growth factor 1 (IGF1), insulin and leptin, and inhibit AKT/mTOR signaling through the upregulation of early growth response protein 1 (EGR1) and the phosphatase and tensin homolog deleted on chromosome 10 (PTEN), thus promoting long-lasting tumor regression and reverting the acquired resistance to chemotherapy [40]. Here, EGR1 is linked to neoplasm.