Recently, Guo et al. (2024) showed that OPN promotes tumor growth and metastasis and GPX4-mediated anti-lipid peroxidation in TNBC by activating the PI3K/Akt/mTOR pathway, elevating cell proliferation, invasive and migratory abilities, tumor sphere formation and angiogenesis [318]. This evidence concerns the gene AKT1 and neoplasm.