COVID-19 patients with the TT genotypes (rs3804099 and rs3804100) decreased the frequency of naïve TLR-2+CD69+ B cells under spike + LPS stimulus (p = 0.0148) (Figure 3B), non-switched TLR-2+CD69+ B cells by spike stimulus (p = 0.0207) (Figure 3C), and switched TLR-2+CD69+ B cells with spike + LPS stimulus (p = 0.0286) (Figure 3D) compared to the unstimulated condition. The gene discussed is TLR2; the disease is COVID-19.