Consequently, altered cell signalling through several key pathways in the pathogenesis of CRC has been described to date, such as APC/Wnt/β-catenin, p53, COX, TGF-β/SMAD, NF-κB, Notch, VEGF, and JAK/STAT3 (reviewed in [37,38]). The gene discussed is APC; the disease is colorectal carcinoma.