CDK6 and invasive carcinoma: Tadano et al., using FFPE tissue samples, showed a progressively decreasing expression of the miR-320 family (except miR-320d) from normal epithelia, across adenoma, to submucosal invasive carcinoma, and concluded that the miR-320 family plays an important role in colorectal tumour growth by targeting CDK6 and should be considered to be a biomarker for its early detection [68].