NUMB and colorectal carcinoma: Numerous miR-31 targets testify to the importance of its role in CRC tumorigenesis, such as factor inhibiting HIF-1α (FIH-1) [212], cyclin-dependent kinase inhibitor 2B (CDKN2B) [213], T lymphoma and metastasis gene 1 (TIAM1) [206], SATB homeobox 2 (SATB2) [214], paired box 6 (PAX6) [215], tensin 1 (TNS1) [216], Rho-related BTB domain containing 1 (RhoBTB1) [217], cell death inducing p53 target 1(CDIP1) [218], NUMB endocytic adaptor protein [219], STX12, eIF4EBP1, and eIF4EBP2 [220], and, in these studies, the role of miR-31 was proven to be both oncogenic and tumour-suppressive.