APC and polyp of large intestine: In frozen tissue samples from porcine models carrying a germline APC mutation, using next-generation sequencing, Stachowiak et al. detected several miRNAs (ssc-let-7e, ssc-miR-98, ssc-miR-126-3p, ssc-miR-146a-5p, ssc-miR-146b, ssc-miR-183, and ssc-miR-196a) associated with early-stage colorectal neoplasia, concluding that the deregulation of these miRNAs could determine progression in colorectal polyps and could be a potential target for early therapy [72].