Additionally, corroborating our observations, a recent study with immune infiltration by intratumoral T cells quantified 18F-fluorodeoxyglucose–PET revealed that high total metabolic tumor volume reflected an inverse association with the numbers of intratumoral CD4- and CD8-positive T cells and a correlation with increased tumor B cell infiltration and high Ki-67 expression [27]. This evidence concerns the gene CD4 and neoplasm.