VWF and hemophilia A: It includes subtypes such as Type 2A, which is characterized by reduced high molecular weight multimers (HMWM), impairing platelet adhesion; Type 2B, with increased VWF affinity for platelets, leading to spontaneous aggregation and bleeding; Type 2M, with reduced binding to platelets without loss of high molecular weight multimers; Type 2N, with defects in VWF binding to factor VIII, mimicking hemophilia A [27].