Indeed, several reports demonstrate various neuropathological similarities of PASC Cognitive Syndrome with AD, including numerous elevated AD marker genes, including FERMT2, HLA-DRB1, GNA15, STAB1, ICA1L, COLGALT1, TNFAIP2, ITGAM, VASP, IDLIA, PVR, TECPR1, several circulatory biomarkers, such as GFAP, NFL, P-tau 181, UCH, NSE, and S100B, and the presence of Apolipoprotein E4 allele (APOE4) [283,285]. This evidence concerns the gene APOE and long COVID-19.