MTOR and Right ventricular hypertrophy: On the basis of these findings, in murine models, which simulate an intermittent system, i.e., two days at high altitude and 2 days at sea level, for a period of 30 days, simulating an altitude of 4600 m, they reported that the mTOR pathway involved in the development of right ventricular hypertrophy is body weight dependent, where weight reduction helps to reduce hypertrophy by inhibiting mTOR through the AMPK pathway [69].