BCL2 and colonic neoplasm: Moreover, an inhibiting effect of XN on the proliferation of HCT 116-derived colon cancer cells (the IC50 decreased from 4.1 μM after 24 h of treatment to 3.6 and 2.6 μM after 48 and 72 h, respectively), as well as a downregulation of the expression of the anti-apoptotic Bcl-2 protein after a 48–72 h incubation of the cells with XN, was observed by Pan et al. [68].