TNF and autoimmune polyendocrinopathy: Other gene polymorphisms associated with APS are detected in the CTLA4 (cytotoxic T lymphocyte antigen 4) gene [10]; the IL2ra gene encoding for IL2Ra (interleukin 2 receptor alpha) (CD25) [11]; the TNFα (tumor necrosis factor alpha) gene [12,13]; the FOXP3 (forkhead box P3) gene, which controls T regulatory cell (Treg) development and function [14]; and MHC class I chain-related gene A (MICA) [15,16].