Several lncRNAs were abnormally expressed in the brain of AD in comparison with the healthy group, shedding light on the strong correlation between aberrant lncRNA expression and the onset and progression of AD pathology, highlighting the pivotal role of lncRNA dysregulation in the pathophysiology of this devastating neurodegenerative disorder, and these abnormally expressed lncRNAs were found to be associated with AD-related pathways, including Aβ and Tau production, clearance, and autophagy [86]. This evidence concerns the gene MAPT and Alzheimer disease.