IL1B and neoplasm: Leinwand, J., et al. [17] and Das, S., et al. [40] found that tumor cell-derived IL-1β, regulated by TLR4 and the pancreatic microbiome, promotes the activation and secretory phenotype of quiescent PSCs and establishes desmoplasia mediated by MDSCs and TAMs to establish an immunosuppressive milieu and promote pancreatic tumorigenesis.