Overall, high expression of histone modifications was correlated with cancers that were positive for steroid receptors, such as the androgen receptor, estrogen receptor, and progesterone receptor, and also had upregulated E-cadherin epithelial marker, breast cancer 1 gene (BRCA1) or downregulated p53 and human epidermal growth factor 2 (HER-2) genes [79]. This evidence concerns the gene ESR1 and cancer.