ACSS2 and hepatocellular carcinoma: In hepatocellular carcinoma (HCC), cells exposed to hypoxia (a condition, in which oxygen is deficient) upregulate acetyl-CoA synthetases (ACSS1 and ACSS2), leading to increased H3 acetylation and the expression of lipogenic genes such as ACACA (acetyl-CoA carboxylase alpha) and FASN (fatty acid synthase).