ALA alleviates motor deficits in PD models by regulating iron metabolism, reducing ROS accumulation and protecting mitochondria, ultimately preventing ferroptosis, a type of iron-driven cell death, through the silent information regulator 1/nuclear factor erythroid 2-related factor 2 (SIRT1/NRF2) signalling pathway [122]. The gene discussed is SIRT1; the disease is Parkinson disease.