TP53 and cancer: In colorectal carcinoma, hypoxia-induced long non-coding RNA (lncRNA) 00205 was shown to bind microRNA (miR)-10a and miR-34c, relieving their suppression of BCL6 mRNAs, with the elevated BCL6 protein then able to block TP53-mediated gene repression, thereby promoting metabolic changes that enhanced cancer progression [109].