BCL6 was first identified as a frequent target gene for chromosomal translocations at chromosome 3q27 in NHL, particularly diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) [1,84], but it was subsequently found to be overexpressed by this and other mechanisms in a range of B cell malignancies extending across B cell lymphomas and leukemias [85]. The gene discussed is BCL6; the disease is non-Hodgkin lymphoma.