The sample sizes of existing and current studies on the relationship between genetic polymorphisms and brucellosis in goats are almost always small (N < 300) [39], which affects the accuracy and persuasiveness of the results to a certain extent; therefore, we investigated the relationship between CTLA4 gene polymorphisms and brucellosis in a large sample size of Shaanbei White Cashmere goats (N > 800) and reported that two InDel loci of the CTLA4 gene exhibited polymorphisms in these animals. This evidence concerns the gene CTLA4 and brucellosis.