Genes such as LYZ, LCN2, CEACAM5, PIK3R3, and FOXQ1 drive CRC progression in precancerous lesions, while CXCL8, ASCL2, and HMGA1 drive early carcinogenesis, validating our conclusions from GeneSwitches, the malignant continuum analysis, and the functional analyses. The gene discussed is LCN2; the disease is colorectal carcinoma.