Genes such as LYZ, LCN2, CEACAM5, PIK3R3, and FOXQ1 drive CRC progression in precancerous lesions, while CXCL8, ASCL2, and HMGA1 drive early carcinogenesis, validating our conclusions from GeneSwitches, the malignant continuum analysis, and the functional analyses. This evidence concerns the gene CXCL8 and colorectal carcinoma.