These targets include BMF, BCL2L11, ETS1, ETS2, CXCL12, IRF2 and TOX. The inhibition of TOX, CXCL12 and IRF suppresses inflammation, which is consistent with the effect of miR-221/-222 and may explain its complex mechanism of action in patients with myocarditis [70]. The gene discussed is CXCL12; the disease is myocarditis.