CD38 and HIV infectious disease: Like our previous analysis, this approach revealed that the number of comorbidities, the frequency of total and naïve CD8 T cells, the frequency of senescent (CD57+), and activated (HLA-DR+CD38+) CD8 T cells, as well as the soluble markers sCD14 and IL-6, were different between both groups of age and the HIV infection status (p-Adj < 0.1 in all cases, Table 2).