TGFB1 and systemic lupus erythematosus: It is interesting that higher expression and levels of Transforming growth factor-β (TGF-β), IL-10, and IL-35 were discovered in patients with newly diagnosed, untreated SLE, produced by Bregs and demonstrating in fact a negative correlation with increasing Systemic Lupus Erythematosus Disease Activity Index SLEDAI score [92].