In fact, numerous animal studies in which TLR7, TLR9, or the related signaling factor Myd88 was deleted demonstrated remission of related auto-antibody production in murine lupus, whereas transgenic over-expression provoked B cell stimulation and formation of germinal centers (GCs) [12,56,57,58,59]. Here, TLR7 is linked to systemic lupus erythematosus.