In this study, to elucidate the contribution of the SERPINB2 gene to the pathogenesis of diabetic kidney disease in the context of type 2 diabetes mellitus (T2DM), we selected four tag single-nucleotide polymorphisms (SNPs) for genotyping in a case-control study of Caucasians. The gene discussed is SERPINB2; the disease is type 2 diabetes mellitus.