Moreover, in prostate cancer cell lines, it has been shown that a loss of PTEN induces activation of PTEN/PI3K/AKT/mTOR, which, in turn, activates the p-PKM2/Erα axis, leading to the up-regulation of Glo2 that is associated with an increase in cell survival, proliferation and cell migration [15]. Here, PTEN is linked to Familial prostate cancer.