Certain oral bacteria, such as Porphyromonas gingivalis, are potential cancer-causing agents that induce oxidative stress via oxidative stress-responsive kinase 1 (OXSR1) and DNA damage, whereas other bacteria, such as Lactobacillus, act as antioxidants that potentially suppress colon cancer [19,20]. Here, OXSR1 is linked to malignant colon neoplasm.