Remarkably, the numbers of non-SNPs with only a moderate impact on a protein structure/function did not significantly differentiate any ovarian tumor groups (Figure S1E), conceivably due to the low frequency of these variants (six such changes were found in only three genes, ATRX, CHEK1, and PTEN (Figure S2D), exclusively in nine hgOvCa tumors (see Supplement-variants.xlsx)). The gene discussed is ATRX; the disease is ovarian neoplasm.