Additionally, among metabolites significantly correlated with Dialister and Bacteroides, five amino acids (asparagine, serine, glutamate, ketoleucine, and valine), which were associated with three pathways of amino acid metabolism, exhibited significant relationships with certain clinic indexes of obesity, such as FBG, ALB, LDL-C, and HDL-C (Figure 7C). The gene discussed is ALB; the disease is obesity due to melanocortin 4 receptor deficiency.