The SKH-hr2+ApoE model exhibited the highest mean number of papillomas (M = 3.233, 95% CI [2.3882, 4.078]), significantly greater than the other models, followed by the SKH-hr2 (M = 1.042) and Nude (M = 0.698) models, with the SKH-hr1 model showing the lowest mean (M = 0.175). Here, APOE is linked to papilloma.