Indeed, CAFs are involved in promoting lymphangiogenesis and angiogenesis and in the formation of a pro-inflammatory tumor microenvironment by secreting growth factors, cytokines, and several chemotactic factors, such as fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and C-X-C motif chemokine ligand 12 (CXCL12) [38,39]. The gene discussed is CXCL12; the disease is neoplasm.