By contrast, some other genes encoding the polymerase II subunits were characterized by higher methylation in carcinomas than in BOTS (e.g., promoters and/or first exons of POLR2G and POLR2L, as well as the distal promoter of POLR2C, and the cds of POLR2E, GR file). The gene discussed is POLR2L; the disease is carcinoma.