CDKN1A and neoplasm: As for another tumor suppressor gene, CDKN1A, we expected it to be hypermethylated in OvCa compared to BOTS, as the high CDKN1A promoter methylation, leading to its low expression, can help cancer cells evade the cell cycle arrest by diminishing the amount of the p21 tumor suppressor, being a product of this gene [39].