Consistently, elevated levels of KRAS, ATR, and Chk1 correlate with the proliferative potential of tumor cells, aneuploidy and the appearance of metastasis in endometrial cancer patients with relapse, indicating that activation of the ATR-Chk1 axis in cooperation with KRAS expression, also increases the risk of recurrence [44]. The gene discussed is CHEK1; the disease is neoplasm.