SCLC can be classified into four subtypes based on transcriptional signatures driven by specific transcription factors: achaete-scute homolog 1 (ASCL1), neurogenic differentiation factor 1 (NEUROD1), yes-associated protein 1 (YAP1), and POU class 2 homeobox 3 (POU2F3). Here, YAP1 is linked to small cell lung carcinoma.