Furthermore, IF staining of irinotecan-treated tumor tissue sections showed elevated OPN, PD-L1, p21Cip1, c-Myc, p65 (NF-κB), ISG15, and survivin, along with lower CyclinD1 compared to the untreated group (Figure 5C–J). The gene discussed is NFKB1; the disease is neoplasm.