Additionally, for LoVo colon cancer cells, irinotecan inhibits mTOR and activates the autophagy-related genes, ULK1, ATG13, ATG4L, and AMBRA1, promoting autophagy with increased numbers of lysosomes and lysosomal activity, which contribute to irinotecan resistance [39]. The gene discussed is AMBRA1; the disease is colonic neoplasm.