CXCL8 and colorectal carcinoma: Furthermore, q-RT-PCR data revealed that SN38 treatment resulted in increased IL8, CCL3, CCL5, and TNFSF11 (RANKL) transcription by approximately 20-, 4-, 6-, and 3-fold, respectively, in various CRC cell lines, which was regulated by the inhibition of NF-κB by Bay or QNZ (Figure 4C–E).