Mice lacking the IL-1 receptor (IL-1R) (IL1r−/−) or deficient in IL1-β developed immunosuppression and multiple epidermal cysts after chronic UVB [24], suggesting that induced somatic events and an altered innate immune response may be involved in the initiation of epidermoid cysts. This evidence concerns the gene IL1R1 and Epidermal Inclusion Cyst.