Mice lacking the IL-1 receptor (IL-1R) (IL1r−/−) or deficient in IL1-β developed immunosuppression and multiple epidermal cysts after chronic UVB [24], suggesting that induced somatic events and an altered innate immune response may be involved in the initiation of epidermoid cysts. The gene discussed is IL1B; the disease is Epidermal Inclusion Cyst.