ZUP1 and cancer: Recurrent amplifications were predominantly noted in DUB/ubiquitin-specific protease 17 (USP17) family, TBC1 domain protein family, and beta-defensins genes (DEFB4B, DEFB103A, DEFB104A, DEFB105A, DEFB106A, DEFB107A, and DEFB131) within the cohort, which overexpression plays a major role in the immune response to cancer [115,116,117,118,119,120].