IL1B and Epidermal Inclusion Cyst: Interestingly, Kulkarni et al. demonstrated that mice lacking the IL-1 receptor (IL-1R) (IL1r−/−) or deficient in IL1-β developed immunosuppression and multiple epidermal cysts after chronic UVB [24], suggesting that induced somatic events and an altered innate immune response may be involved in the initiation of epidermoid cysts, strongly corroborating our findings.