According to recent meta-analyses, the main risk factors include an age exceeding 60, a history of smoking, chronic obstructive pulmonary disease, coronary atherosclerosis, diabetes mellitus, previous radiotherapy (RT), a previous tracheostomy, a low preoperative and postoperative serum albumin and haemoglobin level, a primary tumour stages T3–4, a supraglottic tumour site, an additional pharyngectomy, salvage TLE, and a primary tracheoesophageal puncture [3,4]. This evidence concerns the gene ALB and neoplasm.