It is noteworthy that the secretion of chemokine CXCL13 can induce the expression of lymphotoxin-α1β2 (LTα1β2) on B cells or LTi cells through the CXCL13-CXCR5 axis and form a positive feedback loop, driving the expansion of stromal cells such as cancer-associated fibroblasts (CAFs) and TLSs [5]. This evidence concerns the gene CXCL13 and cancer.