In brief, chemokine signaling is crucial for tumor angiogenesis (CXCR2 and CXCR4 [60]), immunosuppression (CXCR3 and CCR2 [13,35,61]), and tumor progression and metastasis (CCR5 and CXCR6 [61]). Here, CXCR6 is linked to neoplasm.