We found an increase of ACKR4 in GBM-infiltrated pDCs as well as a significant increase in MHCII/ACKR4 double-positive pDCs in tumor-bearing mice (tumor pDC vs. normal pDC: 79.4% vs. 58.8% p < 0.01; tumor pDC vs. tumor mDC: 79.4% vs. 39.3% p < 0.01, Figure 3A,C and Supplemental Figure S3). The gene discussed is ACKR4; the disease is neoplasm.