This study investigates the genetic landscape of thyroid malignancies, with a specific focus on TERTp molecular alterations occurring either alone or alongside other molecular alterations, such as BRAF V600E, RAS, TERTp/EIF1AX/GNAS, and TERTp/EIF1AX/PIK3CA. Our findings provide valuable insights into how these molecular profiles influence disease presentation. Here, PIK3CA is linked to thyroid gland disorder.