Homeobox (HOX) genes (A4, A5, A6, A7, A9, A10, B2, B3, B5, B6) as well as the HOX-related genes, PBX3 and MEIS1, are upregulated in AML NPM1mut samples, while CD34 mRNA levels are low/absent in AML patients with NPM1mut. The gene discussed is PBX3; the disease is acute myeloid leukemia.