While downregulation of HIF-1α via KD of the long non-coding RNA HIF1A-AS2 sensitizes H69AR cells to doxorubicin [166], the role of the HIF-1 pathway and hypoxia in resistance to radiotherapy and other chemotherapeutic agents in SCLC remains to be elucidated. Here, HIF1A is linked to small cell lung carcinoma.