CD8A and small cell lung carcinoma: Another classification scheme replacing SCLC-Y with the inflammatory SCLC-I subtype has been proposed, characterized by low expression of the other transcription factors, an inflamed gene signature, infiltration by cluster of differentiation 8 (CD8)+/programmed cell death 1 ligand 1 (PD-L1)+ T-cells, and improved response to immunotherapy [28].