Furthermore, micro-environmental agonists such as interleukin-10, CD40 ligand, and cytosine guanine dinucleotide–oligodeoxynucleotides (CpG-ODNs) when incubated with MCL and CLL cells can lead to antiapoptotic protein expression through activation of the NF-κB pathway [72]. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.