NFKB1 and mantle cell lymphoma: Furthermore, micro-environmental agonists such as interleukin-10, CD40 ligand, and cytosine guanine dinucleotide–oligodeoxynucleotides (CpG-ODNs) when incubated with MCL and CLL cells can lead to antiapoptotic protein expression through activation of the NF-κB pathway [72].