To verify the role of target genes in AD, 9 genes (MAPK8, NOTCH1, TLR4, AnxA2, APP, CREB1, HIF1A, ITGB1, and KRAS) were selected, GSE5281 and GSE97760 (Figure S5) datasets were brought into our analysis and validation system. The gene discussed is HIF1A; the disease is Alzheimer disease.