NFKB1 and periodontitis: Importantly, paeonol increased NRF2 expression while NRF2 silencing decreased the inhibitory effect of paeonol on NF-κB activation, suggesting that the protective effect of paeonol against periodontitis-induced osteoclastogenesis and alveolar bone loss is mediated by the regulating of the NRF2/NF-κB signaling pathway [73].