Zhang et al. evaluated the effects of BA in rats with experimental periodontitis and found that BA treatment alleviated alveolar bone resorption and reduced interleukin (IL)-1β, Tumor Necrosis Factor (TNF)-α and ROS levels, as well as increased NRF2 protein expression demonstrating that BA can inhibit inflammation and bone loss in periodontitis [55]. This evidence concerns the gene TNF and periodontitis.