This compound may exert important function in periodontitis since notopterol treatment of LPS-stimulated human gingival fibroblasts (HGFs) significantly decreased IL-1β, IL-32, and IL-8 levels by inhibiting the activation of the NF-κB signaling pathway (inhibiting p65 subunit phosphorylation), a known pro-inflammatory signaling pathway [93]. The gene discussed is IL1B; the disease is periodontitis.