KEAP1 and periodontitis: Since the nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2)/Kelch-like ECH-Associated Protein 1 (KEAP1) (NRF2/KEAP1) signaling is the main pathway involved in the regulation of cellular redox homeostasis, several studies have investigated the role of this pathway in periodontitis pathophysiology.