The presence of LPS during periodontitis induces the production of pro-osteoclastogenetic cytokines such as TNF-α, IL-1, IL-6 by osteoblasts and periodontal ligament fibroblasts, T cells, and B cells, leading to the production RANKL, which has a pivotal function in osteoclast differentiation [27]. The gene discussed is TNFSF11; the disease is periodontitis.