Since the nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2)/Kelch-like ECH-Associated Protein 1 (KEAP1) (NRF2/KEAP1) signaling is the main pathway involved in the regulation of cellular redox homeostasis, several studies have investigated the role of this pathway in periodontitis pathophysiology. Here, NFE2L2 is linked to periodontitis.