The main findings of the present study show that (1) LPS and oxidative stress are significantly associated with a hypercoagulation state; (2) LPS and NOX2 are inversely associated with serum albumin; (3) LPS and NOX2 are significantly associated with disease severity; and (4) LPS/albumin ration significantly predicts thrombotic events. The gene discussed is ALB; the disease is thrombophilia.