Similarly, PM exposure was recently found to increase inflammatory cell infiltration in bronchoalveolar lavage fluid and inflammatory responses in lung tissue, including the bronchiolar, perivascular, and alveolar regions, and upregulated the plasma levels of asthma-associated markers such as IgE, IL5, and IL25 in an asthma mouse model established by co-stimulation with PM and ovalbumin (OVA) [83]. This evidence concerns the gene IGHE and asthma.