NOS2 and diabetes mellitus: In a rodent diabetes model, Ishigooka et al. found a positive correlation between angiotensin-converting enzyme (ACE) levels and oxidative stress markers, such as NOX1, NOX4, and inducible nitric oxide synthase (iNOS), and a negative correlation between ACE and SOD, highlighting the connection between RAAS, oxidative stress, and cataract formation [152].