PPARGC1A and type 2 diabetes mellitus: As shown in Figure 1J,K, compared to the Control group, the protein level of PTP1B was upregulated, while PGC-1α was downregulated in the Model group, and the administration of baicalein increased the expression of PGC-1α and decreased the level of PTP1B in T2DM mice both in liver and skeletal muscle tissues.