And ggplot2 programming package (Version: 3.5.1) was used to visualize the results.The results indicated that 157 probable pathways might participate in this process, and the top 3 pathways involved were pathways in cancer, lipid and atherosclerosis, and the PI3K-AKT signaling pathway (Figure 2D and Table S1). This evidence concerns the gene PIK3CA and cancer.